Glossary Term
Selective Estrogen Receptor Modulator
MD
Reviewed By
TRT Authority Medical Team
Selective Estrogen Receptor Modulator (SERM) is a class of drugs that blocks or activates estrogen receptors in specific tissues. Clomiphene citrate, used in TRT, acts as a SERM to stimulate the pituitary gland and boost natural testosterone production without external hormone replacement.