Testosterone Therapy: Complete Guide to Every TRT Delivery Method

The foundation of TRT — injectables, topicals, orals, pellets, and nasal options.

6 medications Evidence-based Clinical sources

Drug Monographs

Topicals

(3)

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Gels, creams, and transdermal patches — topical testosterone delivery methods.

$60

Testosterone Cream

Topical Cream

Compounded (various pharmacies)

A compounded topical testosterone in a cream base, typically applied to the scrotum or other thin-skinned areas for enhanced absorption. Often preferred over gels due to better absorption rates and lower transfer risk when applied to scrotal skin. Available primarily through compounding pharmacies.

Schedule III Continuous absorption Daily

$60–200

Testosterone Gel

Topical Gel

AndroGel, Testim, Vogelxo

A topical testosterone preparation applied daily to the skin, typically on the shoulders, upper arms, or abdomen. Provides steady testosterone absorption without injections. Popular among men who prefer needle-free administration. Requires caution around women and children due to transfer risk.

Schedule III 10-100 min (absorption) Daily

$300

Testosterone Patches

Patch

Androderm

Transdermal patches applied daily to the skin (usually upper arm, back, thigh, or abdomen). Provide consistent testosterone delivery without injections. Less popular than gels due to higher cost, skin irritation, and visibility. Rotation of application sites is required to prevent skin reactions.

Schedule III Continuous transdermal Daily

Pellet

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$300

Testosterone Pellets

Testopel

Small pellets (about the size of a grain of rice) implanted under the skin, typically in the hip or buttock area. Pellets release testosterone steadily over 3-6 months, eliminating the need for frequent injections or daily applications. Requires an in-office procedure for insertion. Most convenient long-term option but least flexible for dose adjustments.

Schedule III Every 3-6 Months

Oral

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$500

Oral Testosterone Undecanoate

Jatenzo, Tlando, Kyzatrex

A newer FDA-approved oral testosterone capsule that absorbs through the lymphatic system rather than the liver, reducing hepatotoxicity concerns that plagued older oral testosterone formulations. Must be taken with food for proper absorption. Offers a needle-free TRT option with twice-daily dosing. Multiple brands now available with slightly different formulations.

Schedule III Twice Daily

Nasal

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Testosterone Nasal Gel (Natesto)

Natesto

Coming soon

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