Testosterone Therapy: Complete Guide to Every TRT Delivery Method
The foundation of TRT — injectables, topicals, orals, pellets, and nasal options.
Drug Monographs
Injectables
(4)Testosterone Cypionate
Depo-Testosterone, PFIZER Cyp
The most commonly prescribed form of injectable testosterone in the United States. Testosterone cypionate is an oil-based injectable that provides steady testosterone levels when administered weekly or bi-weekly. It has a longer half-life than enanthate, making it popular for TRT protocols. Available as both brand name (Depo-Testosterone) and generic/compounded formulations.
Testosterone Enanthate
Delatestryl, Xyosted
A popular oil-based injectable testosterone with a slightly shorter half-life than cypionate. Widely used in TRT protocols, particularly outside the US where it's often more readily available. Functionally very similar to cypionate with comparable effectiveness. Often chosen based on availability and physician preference.
Testosterone Propionate
Testoviron (discontinued in US)
A fast-acting injectable testosterone ester with a very short half-life. Requires frequent injections (every other day or daily) to maintain stable levels. Rarely used for TRT due to injection frequency, but sometimes preferred by bodybuilders for precise control. May cause less water retention than longer esters.
Testosterone Undecanoate (Injectable)
Aveed (US), Nebido (international)
A long-acting injectable testosterone ester administered every 10-14 weeks by a healthcare provider. Provides very stable testosterone levels with minimal peaks and troughs due to its extended release profile. Requires an in-office injection with a mandatory 30-minute post-injection observation period due to rare but serious pulmonary oil microembolism (POME) risk. Ideal for men who want infrequent dosing but are comfortable with clinic visits.
Topicals
(3)Gels, creams, and transdermal patches — topical testosterone delivery methods.
Testosterone Cream
Topical CreamCompounded (various pharmacies)
A compounded topical testosterone in a cream base, typically applied to the scrotum or other thin-skinned areas for enhanced absorption. Often preferred over gels due to better absorption rates and lower transfer risk when applied to scrotal skin. Available primarily through compounding pharmacies.
Testosterone Gel
Topical GelAndroGel, Testim, Vogelxo
A topical testosterone preparation applied daily to the skin, typically on the shoulders, upper arms, or abdomen. Provides steady testosterone absorption without injections. Popular among men who prefer needle-free administration. Requires caution around women and children due to transfer risk.
Testosterone Patches
PatchAndroderm
Transdermal patches applied daily to the skin (usually upper arm, back, thigh, or abdomen). Provide consistent testosterone delivery without injections. Less popular than gels due to higher cost, skin irritation, and visibility. Rotation of application sites is required to prevent skin reactions.
Explore all treatment categories
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