Thyroid Support: Managing Thyroid Health on TRT
Thyroid medications commonly co-prescribed with testosterone therapy.
Drug Monographs
Levothyroxine (Synthroid)
Synthroid, Levoxyl, Tirosint
A synthetic form of the thyroid hormone T4 (thyroxine), used to treat hypothyroidism. Thyroid dysfunction is commonly identified during TRT bloodwork, as thyroid hormones and testosterone interact significantly. Suboptimal thyroid function can cause fatigue, weight gain, and brain fog that overlaps with low testosterone symptoms. Many TRT clinics now screen for and co-manage thyroid issues as part of comprehensive hormone optimization.
Liothyronine (Cytomel)
Cytomel
A synthetic form of the active thyroid hormone T3 (triiodothyronine). While levothyroxine provides the inactive T4 that the body converts to T3, some patients have impaired T4-to-T3 conversion and benefit from direct T3 supplementation. Used alone or in combination with levothyroxine at TRT clinics for patients whose thyroid symptoms persist despite normal T4 levels. Requires more careful dosing due to its potency and shorter half-life.
Explore all treatment categories
Compare medications across all therapeutic categories or connect with a telehealth provider for personalized recommendations.