Weight Management Medications for Men on TRT
GLP-1 agonists and lipotropic injections for metabolic optimization.
Drug Monographs
B12 / MIC Lipotropic Injections
Various compounded formulations
Combination injections containing vitamin B12 and lipotropic compounds (methionine, inositol, choline) that support fat metabolism, energy production, and liver function. A staple offering at TRT and weight loss clinics as a complement to hormone therapy and GLP-1 medications. B12 supports energy and nervous system function while MIC compounds help the liver process and remove fat more efficiently.
Semaglutide
Ozempic, Wegovy, compounded
A GLP-1 receptor agonist originally developed for type 2 diabetes that has become one of the most popular weight loss medications available. Works by mimicking the incretin hormone GLP-1, reducing appetite, slowing gastric emptying, and improving insulin sensitivity. Now widely offered at TRT clinics as men on testosterone often seek concurrent body composition improvement. Weekly injection with progressive dose escalation over several months.
Tirzepatide
Mounjaro, Zepbound, compounded
A dual GLP-1/GIP receptor agonist that has shown even greater weight loss efficacy than semaglutide in clinical trials. Works through two complementary pathways to reduce appetite, improve insulin sensitivity, and enhance fat metabolism. Emerging as a premium weight loss option at TRT clinics. Weekly subcutaneous injection with dose escalation similar to semaglutide.
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